Pathogenesis and damage targets of hypertensive kidney injury

The Pathogenesis of Acute Kidney Injury

Acute kidney injury (AKI) is common in critically ill patients affecting 20 60% of patients (Chertow, et al., 2005; de Mendonca, et al., 2000; Mehta, et al., 2005; Ostermann & Chang, 2008; Silvester, et al., 2001; Uchino, et al., 2005). The exact incidence varies depending on patient population, associated comorbid factors and criteria used to define AKI. Sepsis induced AKI accounts for approxi...

MicroRNAs in Pathogenesis of Acute Kidney Injury.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression mainly by repressing their target gene translation. A large spectrum of human diseases is associated with significant changes in miRNAs. Many miRNAs are induced in diseases, whereas some others are downregulated. The significance of miRNAs has been demonstrated in renal development and physiology, and in major kidney dis...

Critical role of CXCL16 in hypertensive kidney injury and fibrosis.

Recent evidence indicates that inflammation plays a critical role in the initiation and progression of hypertensive kidney disease. However, the signaling mechanisms underlying the induction of inflammation are poorly understood. We found that chemokine (C-X-C motif) ligand 16 (CXCL16) was induced in renal tubular epithelial cells in response to angiotensin II in a nuclear factor-κB-dependent m...

Acute Kidney Injury by Radiographic Contrast Media: Pathogenesis and Prevention

It is well known that iodinated radiographic contrast media may cause kidney dysfunction, particularly in patients with preexisting renal impairment associated with diabetes. This dysfunction, when severe, will cause acute renal failure (ARF). We may define contrast-induced Acute Kidney Injury (AKI) as ARF occurring within 24-72 hrs after the intravascular injection of iodinated radiographic co...

Role of leukocytes in the pathogenesis of acute kidney injury